Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts within the microenvironment and expanding the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific studies have identified recurrent mutations in genes regulating tumor mobile-microenvironment inter... https://hallef677lzx4.webbuzzfeed.com/profile