Lousy/Considerable Metabolizers, CYP2D6 The formation on the active metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Somewhere around seven% from the population has decreased action of your CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme method. These individuals are “bad metabolizers” of debrisoquine, dextromethorphan and tricyclic antidepressants, among other med... https://albertb197agl2.scrappingwiki.com/user