One promising approach to neutralize CSCs is to force them to lose their "stemness" by inducing terminal differentiation, making them sensitive to conventional treatments. Differentiation therapy aims to convert the self-renewing, drug-resistant CSCs into non-tumorigenic, easily eliminated mature cancer cells. Retinoic acid, for example, is used to induce differentiation in acute prom... https://www.beatcancerfoundation.org/